Answer to Question #150101 in Organic Chemistry for ali

Question

Describe the difference of sulfathiazole and sulphadiazine for the treatment of gut infections.

Answer 1

Chemical structure sulfonamides are derived from p-aminobenzenesulphonamide in which p aminobenzoic acid, this a required factor of bacteria for folic acid synthesis. A free amino group at 4th position and sulfonamide group at 1st position are required for antibacterial activity. Aromatic rings(herterocyclic) substituting the sulfonamide enhance this activity by modifying absorption and gastrointestinal tolerance