Answer to Question #111265 in Organic Chemistry for Priya jaiswal

Question #111265
Explain why Hoffman elimination gives less substituted alkene
1
Expert's answer
2020-04-24T13:35:06-0400

Formation of less substituted (less stable) alkene can be explained by two factors involved:

1) Kinetic one: Less substituted "\\beta"-atom of hydrogen is more open for base that approaches H-atom and elimiates it. Substitutes are more bulky than hydrogen, so they less promote hydrogen elimination from C-atom they are attached to. That's why strong and at the same time bulky bases (t-BuO-, i-PrO-) lead to yield increase of Hoffman product more then Zaytsev product (small amounts of Zaytsev's elimination usualy form too)

2) The higher acidity of H of less sustituted C-atom explained by hyperconjugation effect - primary carbanion is more stable then secondary one. Also reaction involves formation of positively charged quaternary amine, that also promotes more acidity for H-atom of less substituted C atom.

These factors show that in given conditions H-atom of less substituted C-atom is more attractive fo bases, and also more cleavable, so reaction goes in that way.


Need a fast expert's response?

Submit order

and get a quick answer at the best price

for any assignment or question with DETAILED EXPLANATIONS!

Comments

No comments. Be the first!

Leave a comment

LATEST TUTORIALS
New on Blog
APPROVED BY CLIENTS