Answer to Question #111014 in Organic Chemistry for kylie

Question

Which of the following compounds is the most reactive nucleophile in an SN2 reaction:

(1) H2O

(2) CH3Cl

(3) CH3COOH

(4) Ph-S-

Answer 1

Solution.

A nucleophile is a particle or molecule that carries a negative charge or an unadjusted electron pair, respectively. From this list the first ingredient is a good nucleophile (due to the presence of 2 lone pairs on the oxygen atom), the second substance is rather the substrate in SN2 reactions, the third substance is a bad nucleophile, and the fourth is the most reactive in SN2 reactions, because of the negative charge of the ion, and accordingly, the three unshared electron pairs on the sulfur atom.

Answer:

4)