(1) A transition state in the reaction is unstable and can be isolated only under extreme experimental conditions (2) An intermediate in a reaction sequence is a species that exists for some finite length of time and can be isolated during an experimental process (3) The activation energy in the reaction is the maximum kinetic energy the molecules must have to overcome the repulsions between the electron clouds when they collide (4) The rate of a reaction is the measure of the stability of the reactants and products
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