Compound 9 is a reversible inhibitor of a human galactosidase, a hydrolytic enzyme which hydrolyses the galactosidic linkage in compound 5 and generates galactose 6 and and hexanol 7. The transition state for this enzymatic reaction has been calculated to resemble 8.
a) Provide a rational why 9 is a potent reversible inhibitor for this enzyme (5 marks) ?
b) Using the calculated transition state 8 for this enzyme, design two potent enzyme transition state inhibitors and rationalize your design strategy (10 marks).
When Copper (II) Sulfide is partially roasted in air (reaction with O2), Copper (I) Sulfide is formed first. Subsequently, upon heating, the copper sulfide thermally decomposes to Copper (I) Oxide and Sulfur Dioxide. Write a balanced equation for these two reactions.