Answer to Question #122555 in Inorganic Chemistry for Mariah

Question

(a) Give a brief account of the platinum complexes that are useful in cancer therapy.
(b) Provide reaction pathways to show how to prepare all the isomers of
[PtCl(CN)(Ph)(PMe3)] from [PtCl4]2-
.
(c) How would you apply 13CNMR and infrared spectra to identify these isomers?

Answer 1

Structure-activity relationships for a class of platinumo coordination compounds confirmed that only those compounds having cis geometryl block cell growth. The most active complex was found to exhibit antitumor activity, whereas its trans isomer showed no such activity. Many derivatives of cisplatin also inhibit growth, and these compounds have at least one N-H group, which is responsible for important hydrogen-bond donor properties, either in the approach of the biological target or the final structure. Many other active Pt(II) compounds are known now, even with trans geometries.