Answer to Question #65118 in General Chemistry for rammie

Question

A drug taken orally, on absorption in the GI tract, is quickly transported to the
liver – the main organ responsible for metabolism.
(a) Using the above information, explain why a large proportion of an orally
active drug, does not reach its target site.

Answer 1

Solution: The active ingredient contained in the medicine gets into the liver. It is in this body there are major changes. Active substances undergo transformation, that is metabolism. Some of the substances absorbed by the body, while others are excreted from the body. Also, some active ingredients and drugs are absorbed in the gastrointestinal tract. However, not all substances get into the liver.