Answer to Question #150652 in General Chemistry for tegran

Question

Is inhibition by sulphonamides reversible? Explain the ways of resistance to
sulphonamides.

Answer 1

There are two types of carbonic anhydrase inhibitors,.We have the N-methyl-substituted sulphonamides and the N-hydroxy-N-methyl substituted sulphonamides. The former is a reversible inhibitor while the latter is an irreversible inhibitor.

In many pathogenic bacteria sulfonamide resistance is mediated by the horizontal transfer of foreign folP or parts of it. Clinical resistance in gram-negative enteric bacteria is plasmid-borne and is effected by genes encoding alternative drug-resistance variants of the DHPS enzymes.