Question

other than by use of 100 uM Ry, give a description of ONE experiment by which you could test the contribution of Ryanodine receptors to changes in [Ca2+]c elicited by angiotensin II

Answer 1

IP3-mediated Ca2+ increases do not involve the ryanodine receptor, but ryanodine receptor antagonists reduce IP3-mediated Ca2+ increases in guinea-pig colonic smooth muscle cells