signal transduction can be affected by change if shape when there is a decrease in the cellular response to a second messenger. The most obvious method for turning off a signal is the dissociation of the ligand from the receptor. Ligand dissociation can be induced (a cellular process),or can occur due to a decrease in the circulating ligand concentration
Signal transduction pathway involves the binding of extracellular signaling molecules and ligands to receptors located on the cell surface or inside the cell that trigger events inside the cell, to invoke a response. The response can then alter the cell's metabolism, shape, and gene expression.
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