Answer to Question #32110 in Molecular Biology for Susan

Question

How is ATP synthase created? What is the DNA sequence that codes for it? How can it be related to the transcription/translation process and how enzymes are created?

Answer 1

ATP synthase consists of 2 regions:1. the F_O portion is within the membrane.
2. The F1 portion of the ATP synthase is above the membrane, inside the matrix of the mitochondria.
The F_O region of ATP synthase is a proton pore that is embedded in the mitochondrial membrane. It consists of three main subunits A,
B, and C, and (in humans) six additional subunits, d, e, f, g, F6, and 8.
Subunit A- Human Gene ATP6, B- ATP5F1, C- ATP5G1, ATP5G2, ATP5G3.
F1-ATP synthase subunits:
Subunit alpha - Human Gene ATP5A1, ATPAF2;
beta - ATP5B, ATPAF1, C16orf7;
gamma - ATP5C1;
delta- ATP5D;
epsilon- ATP5E.