Answer to Question #115974 in Molecular Biology for Ayo

Question

What are the appropriate molecular cytogenetic approaches that should be used to diagnose the following cases? Why? Please explain.

1. Phenotypically abnormal child with balanced 46,XX,t(7;8)(q12;p22) karyotype.
2. A cancer case with a complex translocation that detected by karyotyping, but origins of involved chromosomes was not identified.
3. A balanced translocation carrier woman with recurrent abortions planning a new pregnancy.
4. Bronchial lavage material taken on suspicion of lung cancer
5. A case suspected of having terminal deletion in the short arm of chromosome 5.

Answer 1

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