Answer to Question #97047 in Microbiology for Sanjiban Ghosh

Question

Is a protein confirmation bias, stabilized by weak interaction?

Answer 1

Yes; a polypeptide chain can assume countless different conformations and as a result the unfolded state of a protein is characterized by a high degree of conformational entropy which with hydrogen bonding interactions of many groups in the polypeptide chain with water tend to maintain the unfolded state.