Answer to Question #9480 in Microbiology for Nauman

Question

what is meant by "endogenous parkin" and "endogenous ubiquitin" , i know what is parkin and ubiquitin but what is meant by endogenous here ?

Answer 1

It depens onan ubiquitin is conjugated with endogenous protein substrates or
exogenous. It is possible because ubiquitin introduced this highly conserved
protein as a molecule with extracellular actions or important intracellular
functions. The same meanings are for a parkin protein which is E3-ubiquitin
ligase. It is one of a number of proteins that ubiquitinate the substrate and
mark them for degradation by the proteosome.