Analyses provided evidence of unique lineages in the East‐Caucasian region and also in Central Italy. A phylogenetic analysis revealed that these lineages are basal to the other European DNA sequences. There is a connection between the Western Siberian and Eastern European populations. The North African samples were clustered with the Iberian population. Phylogenetic trees and migration modeling showed a high proximity of Dagestan sequences to those of Central Italy and suggested possible gene flow between Western Asia and Southern Europe which was not related to Northern and Central European lineage.
Our results support the presence of old maternal lineages in two Southern glacial refugia as a legacy of an ancient wave of colonization of Southern Europe from an Eastern origin.
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