Question

Which categories of amino acid would you expect to find on the surface of a soluble protein, and which would you expect to find in the interior?

Answer 1

Amino acids with polar side chains (i.e., serine, threonine, asparagine, glutamine, histidine, etc.) will be located on the surface of a soluble protein whereas amino acids with non-polar side chains (i.e., valine, leucine, isoleucine, alanine, proline, phenylalanine, tryptophan, etc.) will be located in the interior of the protein.