Answer to Question #150466 in Cell Biology for Maria

Question

Sometimes “uncoupling proteins” are present in the inner mitochondrial membrane. When present these provide an alternative pathway for protons to re-enter the matrix. They “uncouple” the ETC from ATP synthesis. What is the result of this “uncoupling”? Give an example of when this might be beneficial.

Answer 1

Uncoupling protein is a mitochondrial protein that uncouples mitochondrial respiration from ATP synthesis, resulting in heat production.Uncoupling protein play a role in normal physiology, as in cold exposure or hibernation, because the energy is used to generate heat instead of producing ATP.