Answer to Question #119803 in Bioinformatics for Christopher

Question

If you want to find more distant homologs in BLAST search, what scoring matrix would you use?

Answer 1

BLOSUM62 scoring matrix is used in Blast to identify distant homologs. This scoring matrix target alignments that show 20-30% identity and can be used for sensitive search and analysis of long full-length sequences. As a result, this matrix provides the identification of distant relationships between sequences.