Question

What does E in E-FAD -> E-FADH2 mean? Does it stand for enzymes FAD is bonded to?

Answer 1

Answer on Question #57386 - Biology - Biochemistry

Question:

What does E in E-FAD -> E-FADH2 mean? Does it stand for enzymes FAD is bonded to?

Solution

FAD is flavin adenine dinucleotide, redox cofactor which can accept or donate electrons one at time or two at a time:

$$\mathrm{FAD} + 2\mathrm{e}^{-} + 2\mathrm{H}^{+} \leftrightarrow \mathrm{FADH}_{2}.$$

In some enzyme-catalyzed reactions the enzyme requires the coenzyme FAD which acts as the electron transporter. The enzyme is bonded with FAD as a cofactor:

$$\mathrm{E} \bullet \mathrm{FAD} \leftrightarrow \mathrm{E} + \mathrm{FAD}.$$

An example is the cleavage of prenylcysteine catalyzed by prenylcysteine lyase. The FAD is non-covalently bound to prenylcysteine lyase. The proposed mechanism for this process is shown below:

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