Answer to Question #57334 in Biochemistry for Sanjukta Ghosh

Question

What does E stand for in E-biotin,prosthetic group of enzyme pyruvate caboxylase?

Answer 1

Pyruvate carboxylase (PC; EC 6.4.1.1), a member of the biotindependent enzyme family, catalyses the ATP-dependent carboxylation of pyruvate to oxaloacetate. This enzyme contains the prosthetic group biotin, which is covalently bound to the ε-amino group of a specific lysine residue. The biotin carboxylase enzymes – E-biotin, where E denotes enzyme.
PC has been found in a wide variety of prokaryotes and eukaryotes. In mammals, PC plays a crucial role in gluconeogenesis and lipogenesis, in the biosynthesis of neurotransmitter substances, and in glucoseinduced insulin secretion by pancreatic islets.