Question #40358

Why is the first enzyme in TCA cycle called citrate synthase and not citrate synthetase?

Expert's answer

Citrate synthase catalyzes the condensation reaction of the acetate residue from acetyl coenzyme A and a molecule of oxaloacetate to form the citrate. However, no ATP is used in this reaction. Synthetases use ATP by definition, therefore, this enzyme is a synthase

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