Question

Explain the cellular regular of glycogenolysis and it interface with glycogenesis at molecular level

Answer 1

Glycogenolysis is the breakdown of glycogen (n) to glucose-1-phosphate and glycogen (n-1). Glycogen branches are catabolized by the sequential removal of glucose monomers via phosphorolysis, by the enzyme glycogen phosphorylase.

The overall reaction for the breakdown of glycogen to glucose-1-phosphate is:^[1]

glycogen_{(n residues)} + P_i ⇌ glycogen_{(n-1 residues)} + glucose-1-phosphate