Answer to Question #274178 in Biochemistry for Water

Question

The malate synthase reaction, which produces malate from acetyl-coA and

glyoxylate in the glyoxylate pathway involves chemistry similar to citrate synthase

reaction. Find out the similarities between these two.

Answer 1

The glyoxylate cycle enables acetyl-CoA to be converted into malate. The glyoxylate cycle occurs in the peroxisomes and converts the acetyl-CoA produced by ß-oxidation of fatty acids into succinate. Then, succinate is converted in malate through the TCA cycle.