Answer to Question #176143 in Biochemistry for linta

Question

Q 2. The first step in the detoxification of ethanol in the liver is its oxidation to form acetaldehyde. This reaction, catalyzed by alcohol dehydrogenase, produces large amounts of NADH. One common effect of alcohol intoxication is the accumulation of lactate in the blood. Can you explain why this effect occurs? 

Answer 1

:- Detoxification of Ethanol in Liver

We define this as

$\bigstar$ Most alcohol is broken down, or metabolized, by an enzyme in your liver cells called alcohol dehydrogenase (ADH) .

$\bigstar$ ADH breaks down alcohol into acetaldehyde, and

$\bigstar$ then another enzyme,aldehyde dehydrogenase (ALDH), rapidly breaks down acetaldehyde into acetate.

One common effect of alcohol intoxication is the accumulation of lactate in the blood

this is Because

Note that :-

$\implies$ Alcohol consumption leads to an accumulation of NADH.

$\implies$This high concentration of NAOH inhibits gluconeogensis by preventing the oxidation of lactate to pyruvate.

$\implies$ In fact , the high concentration of NAOH will cause the reverse reaction to predominate,

$\implies$And lactate will accumulate.